HONG KONG/BEIJING, Dec 1 (Reuters) - China is set to announce an easing of its COVID-19 quarantine protocols in the coming days and a reduction in mass testing, sources told Reuters, a marked shift in policy after anger over the world's toughest curbs fuelled widespread protests.

Cases nationwide remain near record highs but the changes come as some cities have been lifting their lockdowns in recent days, and a top official said the ability of the virus to cause disease was weakening.

Health authorities announcing the easing in their areas have not mentioned the protests - the biggest show of civil disobedience in China for years - which ranged from candle-lit vigils in Beijing to street clashes with police in Guangzhou.

The measures due to be unveiled include a reduction in the use of mass testing and regular nucleic acid tests as well as moves to allow positive cases and close contacts to isolate at home under certain conditions, the sources familiar with the matter said.

That is a far cry from earlier protocols that led to public frustrations as entire communities were locked down, sometimes for weeks, after even just one positive case.

The frustration boiled over last week in demonstrations of public defiance unprecedented in mainland China since President Xi Jinping took power in 2012. The unrest comes as the economy is set to enter a new era of much slower growth than seen in decades.

On Thursday night, Shanghai train commuters reported wirelessly receiving an unsolicited document onto their phones saying that life in China would only get better if there was a full lifting of lockdown and that Xi step down - an apparently new tactic amid a heavy police presence in some cities ahead of the weekend.

CHANGING RULES

Less than 24 hours after violent protests in Guangzhou on Tuesday, authorities in at least seven districts of the sprawling manufacturing hub, said they were lifting temporary lockdowns. One district said it would allow schools, restaurants and businesses including cinemas to reopen.

Cities including Chongqing and Zhengzhou also announced easings.

The sense of official momentum towards a landmark shift built on Thursday as Vice Premier Sun Chunlan, who oversees COVID efforts, told a meeting of frontline experts that the Omicron variant was weakening in its ability to cause disease, allowing China to improve prevention efforts.

"After nearly three years fighting against the epidemic, our country's medical and healthcare system has withstood the test," she said in remarks published by the official Xinhua news agency.

"The vaccination rate of the entire population exceeds 90% and public health awareness and quality has been improved signifciantly," she said.

State media reported Sun saying a day earlier that China was facing a "new situation" in its response to COVID, and urged further "optimisation" of testing, treatment and quarantine policies.

The mention of weakening COVID pathogenicity contrasts with previous messages from a usually hawkish Sun about the deadliness of the virus.

"Sun's (earlier) speech, in addition to the notable easing of COVID control measures in Guangzhou yesterday, sends yet another strong signal that the zero-COVID policy will end within the next few months," analysts at Nomura said in a research note.

"These two events perhaps point to the beginning of the end of zero-COVID."

In the capital, Beijing, some communities have begun preparing for changes.

One community in the east of the city held an online poll this week on the possibility of positive cases isolating at home, residents said.

"I certainly welcome the decision by our residential community to run this vote regardless of the outcome," said resident Tom Simpson, managing director for China at the China-Britain Business Council.

He said his main concern was being forced to go into a quarantine facility, where "conditions can be grim to say the least".

Prominent nationalist commentator Hu Xijin said in a social media post on Wednesday that many asymptomatic carriers of coronavirus in Beijing were already quarantining at home.

RE-OPENING NEXT YEAR?

Expectations have grown around the world that China, while still trying to contain infections, could look to re-open its borders at some point next year once it achieves better vaccination rates among its hesitant elderly.

Health experts warn of widespread illness and death if COVID is let loose before vaccination is ramped up.

Chinese stocks and markets around the world dipped initially after the weekend protests in Shanghai, Beijing and other cities, but later recovered on hopes that public pressure could lead to a new approach by authorities.

More COVID outbreaks could weigh on China's economic activity in the near term, the International Monetary Fund said on Wednesday, adding it saw scope for a safe recalibration of policies that could allow economic growth to pick up in 2023.

China's strict containment measures have dampened domestic economic activity this year and spilled over to other countries through supply chain interruptions.

Following downbeat data in an official survey on Wednesday, the Caixin/S&P Global manufacturing purchasing managers' index showed factory activity shrank in November for a fourth consecutive month.

While the change in tone on COVID appears a response to the public discontent with strict measures, authorities are also seeking out for questioning those present at the demonstrations.

China Dissent Monitor, run by U.S. government-funded Freedom House, estimated at least 27 demonstrations took place across China from Saturday to Monday. Australia's ASPI think tank estimated 51 protests in 24 cities.

(This story has been refiled to fix the writing credit for the story)