Frequency of Acute Kidney Injury in Children Treated with Acyclovir at a Tertiary Care Center 

Background: Acyclovir is a commonly used antiviral medication for treating herpes simplex virus (HSV) infections in children, particularly in neonates. While generally safe, concerns exist about potential kidney injury following acyclovir administration. This study aimed to investigate the frequency of acute kidney injury (AKI) in children treated with acyclovir at a tertiary care center.

Methods: This retrospective study likely analyzed medical records of children admitted to the tertiary care center who received acyclovir therapy for suspected or confirmed HSV infections. The study likely investigated demographic data, underlying medical conditions, acyclovir dosage and duration, concomitant medications, and development of AKI. AKI was likely defined using established criteria, such as changes in serum creatinine or urine output.

Results: The study results will reveal the percentage of children who developed AKI during acyclovir treatment. It will also likely analyze potential risk factors for AKI, such as age, underlying medical conditions, dose of acyclovir, concomitant use of nephrotoxic medications, hydration status, and critical illness requiring PICU admission, inotropic support, or mechanical ventilation.