Systematic review and meta-analysis is positioned at the top of the Evidence-based medicine pyramid. It included numerous stages. In particular, articulating the research idea and ensuring the validity of it is the most important stage. To document your idea, you have to register your idea in databases such as PROSPERO and Cochran collaboration. I will write a comprehensive protocol for your review. Once this step is completed, an extensive systematic literature review will be done succeeded by the screening process to reveal which articles will finally be included in your review. Subsequent to that, data will be extracted from the final included papers and will be prepared prior to meta-analysis.